Arrhythmias & electrophysiology
Determinants of invasive left atrial pressure in patients with atrial fibrillation
Authors' conclusion
LA structure and function assessment well correlates with mean LAP in patients with a history of AF.
Study context
- Population
- Patients undergoing transcatheter ablation for atrial fibrillation (AF); echocardiography within 24 h before invasive left atrial pressure (LAP) measurement
- Participants
- 101 patients
- Exposure
- Normal vs increased mean LAP
- Normal LAPn = 47reference
- Increased LAPn = 54
- Outcome
- Association of cardiac structure and function with invasive mean left atrial pressure (LAP)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Independent associations with mean LAP (multivariable)
- Higher E/e' ratio
- P = 0.041
- Higher minimal LAV index (LAVI min)
- P = 0.031
- Lower peak atrial longitudinal strain
- P = 0.030
- Lower right ventricular (RV) free wall longitudinal strain
- P = 0.037
- Maximal LAV index (LAVI max) not significantly associated
- P = 0.137
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Diagnostic accuracy for elevated LAPBest diagnostic accuracy | LAVI min AUC 0.703 |
Increased vs normal LAP: cardiac structure and function
- No significant differences in clinical characteristics
- Increased LAP: lower left ventricular (LV) global longitudinal strain, larger LA volumes, worse RV function
Original publication
Determinants of invasive left atrial pressure in patients with atrial fibrillation. Eur Heart J Cardiovasc Imaging. Published 29 July 2024. doi:10.
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