Negative Predictive Value and Prognostic Associations of Rb-82 PET/CT with Myocardial Blood Flow in Cardiac Allograft Vasculopathy (CAV)
Authors' conclusion
An algorithm using PET/CT scanning with MBF demonstrates high a negative predictive value for CAV. PET CAV 2/3 is associated with a higher risk of adverse events and need for revascularization.
Study context
- Population
- Heart transplant recipients without prior revascularization who underwent PET/CT with myocardial blood flow (MBF)88 diagnostic, 401 prognostic
- Exposure
- PET/CT with MBF vs invasive coronary angiography (ICA) for CAV screening
- Outcome
- Diagnostic accuracy for moderate to severe CAV by ICA (PET/CT within 1 year of ICA); prognostic composite of HF hospitalization, MI, retransplantation and all-cause mortality
Main finding
As reported in the abstract
Moderate to severe CAV by ICA
| Group | PPV | NPV |
|---|---|---|
| PET CAV 0 | — not stated in the abstract | 97% |
| PET CAV 2/3 | 68% | — not stated in the abstract |
PPV
PET CAV 0— not stated in the abstract
PET CAV 2/368%
NPV
PET CAV 097%
PET CAV 2/3— not stated in the abstract
— not stated in the abstract
Observational data: associations, not effects.
Further findings
Annualized adverse event rate (HF hospitalization, MI, retransplantation, all-cause mortality) · median 1.2 (IQR: 1.0-1.8) years
P < 0.001
- Annualized adverse event rate (HF hospitalization, MI, retransplantation, all-cause mortality) — Patients with an adverse event
- 46
Original publication
Negative Predictive Value and Prognostic Associations of Rb-82 PET/CT with Myocardial Blood Flow in CAV. JACC Heart Fail. Published 11 January 2023. doi:10.
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