Arrhythmias & electrophysiology
Neuropeptide Y as a Prognostic Biomarker in Electrical Storm
Authors' conclusion
NPY emerges as a potential biomarker for risk stratification in patients experiencing ES.
Study context
- Population
- Patients diagnosed with electrical storm (ES), including drug-refractory ESpatients diagnosed with ES
- Participants
- 95 patients
- Exposure
- Low neuropeptide Y (NPY) group vs high NPY group, divided according to NPY threshold; refractory group vs control group
- Control groupn = 62
- Refractory groupn = 33
- Outcome
- Venous NPY levels
- Follow-up
- In hospitalization
Main finding
As reported in the abstract
- Significantly higher venous NPY levels in the refractory group compared with the control group
Observational data: associations, not effects.
Further findings
Mortality by baseline NPY level (Cox proportional hazards)
- Elevated baseline NPY levels significantly associated with an increased risk for mortality (95% CI)
- 0.89-0.99
Survival (Kaplan-Meier), high vs low NPY
- Clear divergence of survival curves between patients with high and low NPY levels
ROC analysis for NPY threshold
- NPY threshold
- 44.4 pg/mL
- Sensitivity
- 0.91
- Specificity
- 0.90
- Youden's index applied to identify the optimal cutoff point
Original publication
Neuropeptide Y as a Prognostic Biomarker in Electrical Storm. JACC Clin Electrophysiol. Published 5 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →