Heart failure & cardiomyopathies
Neuropeptide Y is Elevated in Heart Failure and is an Independent Predictor of Outcomes
Authors' conclusion
Peripherally measured NPY is an independent predictor of all-cause and cardiovascular death even after adjustment for other prognostic variables, including BNP.
Study context
- Population
- Heart failure (HF) patients with a range of left ventricular ejection fraction (LVEF); peripheral venous Neuropeptide Y (NPY)
- Participants
- 833 patients
- Exposure
- High NPY vs low NPY
- Outcome
- Composite of:
- CV death or HF hospitalization
- Its components
- All-cause mortality
Methodological detailsThreshold of elevated NPY identified through binary recursive partitioning
- Threshold of elevated NPY identified through binary recursive partitioning
Main finding
As reported in the abstract
High NPY vs Low NPYAdjusted hazard ratio (95% CI)P value
CV death
1.56(1.21–2.10)
P = 0.003All-cause death
1.30(1.04–1.62)
P = 0.02Observational data: associations, not effects.
Further findings
NPY level, whole cohort
- Mean NPY
- 25.8 ± 18.2 pg/ml
Original publication
Neuropeptide Y is Elevated in Heart Failure and is an Independent Predictor of Outcomes. Eur J Heart Fail. Published 21 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →