Heart failure & cardiomyopathies
Association of Anaemia on Heart Failure and Left Ventricular Function: A Bidirectional Mendelian Randomization Study
Main finding · HF risk (genetically predicted anaemia)Result — go to the resultOdds ratio 1.12 95% CI 1.04–1.20Authors' conclusion
This MR study supports the genetic evidence that there is bidirectional causality between anaemia and the risk of HF as well as anaemia may cause left ventricular hypertrophy and enlargement of the left atrium.
Study context
- Comparison
- Genetically predicted anaemia and heart failure (HF) risk, LV structure and function; reverse direction HF on anaemia
- Outcome
- HF risk
Methodological detailsreverse-direction Mendelian randomization (MR) analysis
- Reverse-direction MR analysis
Main finding
HF risk (genetically predicted anaemia)
Odds ratio
1.12
95% CI 1.04–1.20
P = 0.002
Genetically predicted anaemia
OR 1.12 (95% CI 1.04–1.20); P = 0.002
As reported in the abstract
Further findings
Anaemia risk (genetic susceptibility to HF; reverse-direction MR)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Genetic susceptibility to HFMeta | 1.40 (1.24–1.59) | P = 1.79 × 10-7 | |
| 0.512Odds ratio (log scale) |
| Outcome | β (95% CI) | P value |
|---|---|---|
| LV structure and function (genetically predicted anaemia)Genetically predicted anaemia · LV mass index | 1.051 (0.384–1.718) | P = 0.002 |
| LV structure and function (genetically predicted anaemia)Genetically predicted anaemia · LV mass | 2.063 (0.578–3.547) | P = 0.006 |
| LV structure and function (genetically predicted anaemia)Genetically predicted anaemia · left atrial minimum volume | 0.076 (0.008–0.143) | P = 0.028 |
| LV structure and function (genetically predicted anaemia)Genetically predicted anaemia · left atrial maximum volume | 0.090 (0.023–0.157) | P = 0.009 |
Original publication
Association of Anaemia on Heart Failure and Left Ventricular Function: A Bidirectional Mendelian Randomization Study. ESC Heart Fail. Published 20 November 2023. doi:10.
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