Heart failure & cardiomyopathies
Neuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank
Authors' conclusion
Greater tendency towards neuroticism personality traits is linked to smaller, poorer functioning ventricles with lower LV mass, higher myocardial fibrosis, and higher arterial stiffness. These relationships are independent of traditional vascular risk factors and are more robust in men than women.
Study context
- Population
- UK Biobank participants with cardiovascular magnetic resonance (CMR) and neuroticism score (12-item Eysenck Personality Questionnaire-Revised Short Form)47.8% men
- Participants
- 36,309 participants
- Outcome
- CMR measures of LV and RV structure and function, and arterial compliance, by neuroticism score
Methodological detailsUK Biobank, multivariable linear regression
- UK Biobank
- Multivariable linear regression
Main finding
As reported in the abstract
Association of higher neuroticism score with CMR metrics (adjusted)
- Smaller left ventricular (LV) and right ventricular (RV) end-diastolic volumes, lower LV mass, greater concentricity (higher LV mass to volume ratio), higher native T1
- Poorer LV and RV function (lower stroke volumes) and greater arterial stiffness
- Adjusted for age, sex, obesity, deprivation, smoking, DM, hypertension, hypercholesterolaemia, alcohol, exercise, education
Observational data: associations, not effects.
Further findings
Sex-stratified analyses
- Women: associations with LV stroke volume, concentricity and arterial stiffness attenuated
- Men: associations remained robust (except native T1)
Original publication
Neuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank. Eur Heart J Cardiovasc Imaging. Published 13 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →