Valvular & structural heart disease
New-Onset Conductance Disturbances After Transcatheter Tricuspid Valve Replacement: A Mechanistic Assessment
Authors' conclusion
NOCD incidence was 44.6% after TTVR in a highly selected patient population. Baseline hyperdynamic right ventricular function and contact of the device with the MS were independently associated with NOCD at 30 days.
Study context
- Population
- Patients undergoing transcatheter tricuspid valve replacement (TTVR)
- Participants
- 70 patients
- Exposure
- New-onset conductance disturbance (NOCD)+ vs NOCD- after TTVR
- NOCD+n = 31
- Outcome
- NOCD incidence
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Developed NOCD (RBBB, complete AV block, slow AF)
31
44.3%
Observational data: associations, not effects.
Further findings
Type IIIB leaflet morphology
P = 0.049
Postprocedural white blood cell count peak >13 × 109/L
P = 0.046
| Outcome | NOCD+ | NOCD- | P value |
|---|---|---|---|
| Baseline absolute RV free wall longitudinal strain | 29.7% ± 5.4% | 25.1% ± 6.4% | P = 0.002 |
New permanent pacemaker implantation · 30 days
- New permanent pacemaker
- 8 patients (14%)
Membranous septum dimensions, device oversizing
- No difference
Predictors of NOCD (logistic regression)
- Associated with baseline absolute RV free wall longitudinal strain ≥29% and subvalvular device contact with the membranous septum (MS) on follow-up CT
Original publication
New-Onset Conductance Disturbances After Transcatheter Tricuspid Valve Replacement: A Mechanistic Assessment. JACC Cardiovasc Interv. Published 14 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it