Coronary disease & ACSCohort study
Non-stenotic fibro-calcific aortic valve as a predictor of myocardial infarction recurrence
- Retrospective cohort study
- single-centre
- consecutive patients
- study and test cohorts
- topological data analysis
Authors' conclusion
AVSc is a crucial variable for identifying AMI patients at high risk of recurrent AMI
Study context
- Population
- Consecutive acute myocardial infarction (AMI) patients admitted at Centro Cardiologico Monzino (2010–19), followed up for 5 yearsstudy n = 1070
- Participants
- 2,530 patients
- Exposure
- High-risk topological data analysis (TDA) subgroups vs other subgroups; AVSc vs no AVSc
- Outcome
- Recurrent AMI (re-infarction)
- Follow-up
- 5 years
Main finding
As reported in the abstract
Re-infarction
Two highest-risk subgroups vs Other subgroupsHazard ratio (95% CI)
study cohort; combined HR
3.8(2.7–5.4)
test cohort
3.1(2.2–4.3)
Observational data: associations, not effects.
Further findings
AVSc and re-infarction risk, year-by-year analysis (adjusted for all confounders) · all time points
- AVSc independently associated with increased re-infarction risk, OR ∼2, in study and test cohorts
- all P < 0.01
Original publication
Non-stenotic fibro-calcific aortic valve as a predictor of myocardial infarction recurrence. Eur J Prev Cardiol. Published 14 February 2024. doi:10.1093/eurjpc/zwae062
Summarised from the published abstract; every number is checked against it