Coronary disease & ACSCohort study
Nonfatal Adverse Events and Risk for Subsequent Mortality in Patients Undergoing Percutaneous Coronary Intervention
- Prospective registry cohort study
- multicentre
- time-varying exposures
- death as competing risk
Authors' conclusion
HFH shows stronger associations with mortality than ACS or major bleeding following PCI, suggesting that adverse events should not be weighted equally
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI), Japanese multicentre prospective registry (2008–2021)median follow-up 730 days
- Participants
- 10,482 patients
- Exposure
- Heart failure hospitalization (HFH) vs acute coronary syndrome (ACS) vs Major bleeding
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Main finding
As reported in the abstract
All-cause mortality after nonfatal event (time-varying)
Adjusted hazard ratio (95% CI)
HFH
6.11(4.76–7.85)
ACS
3.22(2.14–4.84)
Major bleeding
2.62(1.71–4.02)
Observational data: associations, not effects.
Further findings
| Outcome | HFH | ACS | Major bleeding |
|---|---|---|---|
| 2-year cumulative incidence | 4.7% (95% CI 4.2%–5.1%) | 3.4% (95% CI 3.0%–3.7%) | 2.5% (95% CI 2.2%–2.8%) |
| Population attributable fraction of mortality | 20.1% (95% CI 19.0%–21.0%) | 4.3% (95% CI 3.3%–4.9%) | 2.9% (95% CI 1.9%–3.5%) |
- 2-year cumulative incidence — Any adverse event
- 1,021 (9.7%; 95% CI: 9.2%-10.3%)
Original publication
Nonfatal Adverse Events and Risk for Subsequent Mortality in Patients Undergoing Percutaneous Coronary Intervention. JACC Cardiovasc Interv. Published 16 March 2026. doi:10.1016/j.jcin.2026.02.010
Summarised from the published abstract; every number is checked against it