Aortic & peripheral vascular diseaseCohort study
Noninvasive Thrombus Imaging in Patients With Ischemic Stroke
- Prospective cohort study
- single-centre
- observational
- blinded readers
Authors' conclusion
Noninvasive thrombosis imaging is a novel technique that enables direct in vivo identification of thrombus formation and frequently reveals the source of thromboembolism in patients with acute ischemic stroke.
Study context
- Population
- Patients with acute ischaemic stroke undergoing hybrid [18F]GP1 positron emission tomography (PET)/CT angiography within 21 days of symptom onset
- Participants
- 100 patients
- Exposure
- Cardiovascular [18F]GP1 uptake vs no uptake
- [18F]GP1 uptaken = 63
- Outcome
- Identification of the source of in vivo cardiovascular thromboembolism by [18F]GP1 PET/CT angiography
Main finding
As reported in the abstract
Cardiovascular [18F]GP1 uptake indicative of thrombosis
Participants with cardiovascular [18F]GP1 uptake (nearly two-thirds)
63
Stroke classification changed (over a quarter)
26
Thrombus source identified in stroke of undetermined cause
18 of 41 (44%)
Observational data: associations, not effects.
Further findings
| Outcome | fold increased risk (95% CI) | P value |
|---|---|---|
| Recurrent stroke or TIA · median follow-up 613 (interquartile interval, 251-788) days | 10.4 (1.35–79.40) | P = 0.024 |
- Recurrent stroke or TIA — Recurrent stroke or TIA
- 14
- Recurrent stroke or TIA — Of these, with baseline cardiovascular [18F]GP1 uptake
- 13 (93%)
Original publication
Noninvasive Thrombus Imaging in Patients With Ischemic Stroke. Circulation. Published 1 September 2026. doi:10.1161/circulationaha.126.080420
Summarised from the published abstract; every number is checked against it