Heart failure & cardiomyopathies
Normal abundance of immune cells in left ventricular myocardium from patients with heart failure and preserved ejection fraction
Authors' conclusion
Spatially resolved human myocardial profiling did not demonstrate an increase in immune lineage cells in preclinical or overt HFpEF, challenging the concept that myocardial immune cell infiltration is a major driver of HFpEF.
Study context
- Population
- Adults undergoing elective CABG with preserved LVEF (≥50%); Left ventricular (LV) epicardial biopsies
- Participants
- 28 adults
- Exposure
- Heart failure with preserved ejection fraction (HFpEF) Stage B and Stage C vs referent controls
- Controlsn = 10reference
- HFpEF Stage Bn = 10
- HFpEF Stage Cn = 8
- Outcome
- Abundance and phenotypic composition of immune lineage cells in LV myocardium (spatial transcriptomics, immunofluorescence for CD45, CD68, CD3G)
Main finding
As reported in the abstract
Immune cell abundance (spatial transcriptomics)
- No differences across groups
- P = NS
Observational data: associations, not effects.
Further findings
Immune cells by immunofluorescence (CD45, CD68, CD3G)
- Immunofluorescence confirmed absence of differences
Baseline characteristics
- HFpEF patients older and more obese than controls
Original publication
Normal abundance of immune cells in left ventricular myocardium from patients with heart failure and preserved ejection fraction. Eur J Heart Fail. Published 10 February 2026. doi:10.
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