Heart failure & cardiomyopathies
Left Ventricular Gene Expression in Heart Failure With Preserved Ejection Fraction—Profibrotic and Proinflammatory Pathways and Genes
Authors' conclusion
The transcriptome analysis of left ventricular myocardial samples from patients with HFpEF confirms an overabundant extracellular matrix gene expression, the basis of myocardial fibrosis, without a signature of activated proinflammatory pathways or genes.
Study context
- Population
- Patients undergoing aortocoronary bypass surgery with epicardial LV biopsies
- Participants
- 16 vs 14
- Comparison
- Heart failure with preserved ejection fraction (HFpEF) vs referent controls
- HFpEFn = 16
- CTRn = 14reference
- Outcome
- LV transcriptome (RNA sequencing)
Main finding
As reported in the abstract
- Differentially expressed genes, many in profibrotic pathways (extracellular matrix production, posttranslational modification)
- 477
Further findings
BMI · HFpEF patients were hypertensive
P < 0.01
NT-proBNP
P < 0.001
Original publication
Left Ventricular Gene Expression in Heart Failure With Preserved Ejection Fraction—Profibrotic and Proinflammatory Pathways and Genes. Circ Heart Fail. Published 27 July 2023. doi:10.
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