Arrhythmias & electrophysiology
Novel insight into neurofilament light chain and rhythm outcomes after catheter ablation of new-onset atrial fibrillation: A prospective cohort study
Main finding · AF recurrenceResult — go to the resultAdjusted hazard ratio 3.756 95% CI 1.392–10.136Authors' conclusion
NFL may serve as an effective biomarker for risk stratification and therapeutic decision-making in patients with new-onset AF who have undergone catheter ablation.
Study context
- Population
- Patients newly diagnosed with atrial fibrillation (AF) undergoing catheter ablation29 with AF recurrence
- Participants
- 215 patients
- Exposure
- High NFL vs lower NFL
- Outcome
- AF recurrence during follow-up
- Follow-up
- Average 10.69 months
Methodological detailsconsecutive patients, Serum NFL measured by enzyme-linked immunosorbent assay
- Consecutive patients
- Serum NFL measured by enzyme-linked immunosorbent assay
Main finding
AF recurrence
Adjusted hazard ratio
3.756
95% CI 1.392–10.136
High NFL (≥300 pg/mL)vs lower NFL
adjusted HR 3.756 (95% CI 1.392–10.136)
As reported in the abstract
Observational data: associations, not effects.
Further findings
AF recurrence by subgroup (age >65 years, gender, hypertension, paroxysmal AF)
- Associations between NFL levels and AF recurrence consistent across subgroups
Dose-response (restricted cubic spline)
- Consistent linear relationship across the entire range of NFL levels
Incremental prediction of recurrent AF when NFL added to CHA2DS2-VASc score model
- Net reclassification improvement: HR 0.464; 95% CI 0.226-0.675
- P < 0.05
- Integrated discrimination improvement: HR 0.087; 95% CI 0.017-0.183
- P = 0.08
- Significantly improved prediction (time-dependent AUC and decision curve analysis)
Original publication
Novel insight into neurofilament light chain and rhythm outcomes after catheter ablation of new-onset atrial fibrillation: A prospective cohort study. Heart Rhythm. Published 27 August 2024. doi:10.
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