Arrhythmias & electrophysiology
Novel risk predictor of arrhythmias for patients with potassium channel–related congenital long QT syndrome
Authors' conclusion
Our findings suggest that in patients with LQTS, dynamic QT interval measures obtained during the EST are associated with lifetime arrhythmic events and events after the EST.
Study context
- Population
- Patients with long QT syndrome (LQTS) type 1 and LQTS type 2discovery 695
- Exposure
- Symptomatic vs asymptomatic patients
- Outcome
- Recovery-rest ΔQTc (QTc change between rest and 3-4 min recovery on EST)
Methodological detailsdiscovery and validation cohorts
- Discovery and validation cohorts
Main finding
As reported in the abstract
Optimal cutoff LQTS type 1, significantly associated with cardiac events
35 ms
Optimal cutoff LQTS type 2, significantly associated with cardiac events
16 ms
Observational data: associations, not effects.
Further findings
Sensitivity analyses: on and off β-blockers; baseline QTc below vs above 470 ms
- Consistent findings
Original publication
Novel risk predictor of arrhythmias for patients with potassium channel–related congenital long QT syndrome. Heart Rhythm. Published 14 December 2024. doi:10.
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