Heart failure & cardiomyopathies
Obesity-Related Biomarkers Are Associated With Exercise Intolerance and Heart Failure with Preserved Ejection Fraction (HFpEF)
Authors' conclusion
Specific obesity-related pathways including inflammation, adipokine signaling, and insulin resistance may underlie the association of obesity with HFpEF and exercise intolerance.
Study context
- Population
- Patients with LVEF ≥50% and chronic dyspnea undergoing clinically indicated cardiopulmonary exercise test with invasive hemodynamic monitoring, 2006–2017
- Participants
- 509 patients
- Exposure
- Obesity-related biomarkers vs HFpEF status and exercise capacity
- Outcome
- Association of obesity-related biomarkers with HFpEF and exercise capacity
Methodological detailsconsecutive patients, invasive hemodynamic monitoring, multivariable-adjusted logistic regression
- Consecutive patients
- Invasive hemodynamic monitoring
- Multivariable-adjusted logistic regression
Main finding
As reported in the abstract
- All biomarkers associated with lower peak VO2
- P≤0.002
- 1-SD higher leptin: 2.35 mL/kg per min lower peak VO2 (β, −2.35±0.19)
- P<0.001
- Leptin associated with odds of HFpEF: OR
- 1.36 (95% CI 1.09-1.70)
- Chronotropic response (CRP) associated with odds of HFpEF: OR
- 1.25 (95% CI 1.03-1.52)
Observational data: associations, not effects.
Further findings
Exercise reserve: BP response
- HOMA-IR, leptin, adiponectin associated with BP reserve
- P ≤ 0.002
Exercise reserve: chronotropic response
- CRP, IL-6, HOMA-IR, leptin and resistin associated with chronotropic response
- P < 0.05
Original publication
Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF. Circ Heart Fail. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →