Office measurement vs. ambulatory blood pressure monitoring: associations with mortality in patients with or without diabetes
Authors' conclusion
Diabetes increased the risk for all-cause death, CV, and non-CV death at every level of office and ambulatory BP. Masked and sustained hypertension confer to the highest risk, while white-coat hypertension appears grossly neutral without interaction of relative risk between diabetes and no diabetes.
Study context
- Population
- Patients in the Spanish ambulatory BP monitoring (ABPM) Registry, 223 primary care centres in Spain
- Participants
- 59,124 patients223 primary care centres
- Exposure
- Diabetes vs no diabetes across office and ambulatory blood pressure (BP) levels and hypertension phenotypes
- Diabetesn = 11,391
- Outcome
- CV death and all-cause death by office, 24-h, daytime and nighttime ambulatory BP and by hypertension phenotype
Methodological detailsmulticentre, adjusted Cox regression
- Multicentre
- Adjusted Cox regression
Main finding
As reported in the abstract
White-coat hypertension vs NormotensionHazard ratio (95% CI)
CV death
0.86(0.72–1.03)
All-cause death, no diabetes
0.89(0.81–0.98)
- Relative association of BP to cardiovascular (CV) death risk similar in diabetes vs no diabetes (mean, daytime, nighttime interaction P)
- P = 0.80; P = .97; P = .32
- Phenotype × diabetes interaction, CV death
- P = 0.26
- Phenotype × diabetes interaction, all-cause death
- P = 0.043
- Phenotype × diabetes interaction, non-CV death
- P = 0.053
Observational data: associations, not effects.
Original publication
Office measurement vs. ambulatory blood pressure monitoring: associations with mortality in patients with or without diabetes. Eur Heart J. Published 7 June 2024. doi:10.
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