Arrhythmias & electrophysiology
Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation
Authors' conclusion
In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF.
Study context
- Population
- Participants of prospective cohorts with baseline blood or adipose tissue omega-3 fatty acid levels
- Participants
- 54,799 participants · 17 cohorts
- Comparison
- Higher vs lower blood or adipose tissue omega-3 fatty acid levels
- Outcome
- Incident AF
- Follow-up
- Median 13.3 years
Methodological detailsparticipant-level meta-analysis, global consortium of 17 prospective cohorts, prespecified analytical plan, harmonized definitions, inverse-variance weighted meta-analysis
- Participant-level meta-analysis
- Global consortium of 17 prospective cohorts
- Prespecified analytical plan
- Harmonized definitions
- Inverse-variance weighted meta-analysis
Pooled result
As reported in the abstract
median 13.3 years
Estimate (95% CI)
EPA
HR per interquintile range 1.00(0.95–1.05)
DPAhigher levels
HR 0.89(0.83–0.95)
DHAhigher levels
HR 0.90(0.85–0.96)
EPA+DHAhigher levels
HR 0.93(0.87–0.99)
- Incident AF cases
- 7,720
Original publication
Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation. J Am Coll Cardiol. Published 25 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it