Valvular & structural heart disease
One-year follow-up of patients with severe tricuspid regurgitation: prognostic impact of right heart failure staging
Authors' conclusion
Massive and torrential TR identify patients at the highest risk. The modified RHFS stratifies patients with STR into prognostic categories and may help guide the timing of intervention.
Study context
- Population
- Consecutive patients with severe tricuspid regurgitation (STR) enrolled from 48 centres over 6 monthspatients included (mean age 76.7 ± 10.5 years, 70.2% women)
- Participants
- 1,247 patients
- Exposure
- Prognostic impact of a modified right heart failure staging
- Outcome
- HF hospitalization
- Follow-up
- During
Methodological detailsprospectively enrolled consecutive patients, 48 centres, 1-year follow-up, multivariable analysis
- Prospectively enrolled consecutive patients
- 48 centres
- 1-year follow-up
- Multivariable analysis
Main finding
As reported in the abstract
HF hospitalization
20.8%
Observational data: associations, not effects.
Further findings
HF hospitalization, Stages III-IV of the modified right heart failure staging (RHFS)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Stages III-IV of the modified RHFSMultivariable analysis; comparator not stated · independently associated | 1.58 (1.13–2.23) | P = 0.008 | |
| 0.512Hazard ratio (log scale) |
Cardiovascular mortality, Stages III-IV of the modified RHFS
| HR (95% CI) | P value | ||
|---|---|---|---|
| Stages III-IV of the modified RHFSMultivariable analysis; comparator not stated · independently associated | 2.01 (1.27–3.18) | P = 0.003 | |
| 0.20.5125Hazard ratio (log scale) |
Cardiovascular mortality, by TR severity
| HR (95% CI) | P value | ||
|---|---|---|---|
| Massive TRComparator not stated | 1.72 (1.02–2.91) | P = 0.041 | |
| Torrential TRComparator not stated | 2.57 (1.24–5.34) | P = 0.011 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Severe TR | Massive TR | Torrential TR |
|---|---|---|---|
| TR severity distribution | 64.9% | 24.1% | 11.0% |
Cardiovascular death · During follow-up
- Cardiovascular death
- 9.2%
Tricuspid intervention · During follow-up
- Underwent tricuspid intervention
- 12.3%
Aetiology
- V-STR due to left-heart disease (most frequent)
- 49.9%
- A-STR
- 19.8%
Original publication
One-year follow-up of patients with severe tricuspid regurgitation: prognostic impact of right heart failure staging. ESC Heart Fail. Published 17 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →