Arrhythmias & electrophysiology
Opioid prescription and risk of atrial fibrillation in younger veterans
Main finding · Incident AFResult — go to the resultHazard ratio 1.47 95% CI 1.38–1.57Authors' conclusion
Our findings suggest opioid prescription may be a modifiable risk factor for the development of AF.
Study context
- Population
- Post-9/11 veterans enrolled in the Veterans Health Administration (VHA)mean age 34 years, 13.24% female
- Participants
- 609,763 veterans
- Exposure
- Prescribed opioids vs no opioid use
- Opioidsn = 124,395
- Outcome
- Incident AF
Methodological detailstime-updated Cox regression, national
- Time-updated Cox regression
- National
Main finding
As reported in the abstract
Hazard ratio
1.47
95% CI 1.38–1.57
Opioidsvs No opioid use
HR 1.47 (95% CI 1.38–1.57)
- Veterans diagnosed with atrial fibrillation (AF) (overall)
- 1,455 (0.24%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident AF by opioid typeImmunomodulating opioidsvs No opioid useAdjusted | 1.40 (1.25–1.57) | |
| Incident AF by opioid typeNonimmunomodulating opioidsvs No opioid useAdjusted | 1.49 (1.39–1.60) | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Opioid prescription and risk of atrial fibrillation in younger veterans. Am Heart J. Published 9 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →