Heart failure & cardiomyopathies
Oral anticoagulation in patients with left ventricular thrombus: a systematic review and meta-analysis
Authors' conclusion
In this comprehensive analysis of mainly observational data, the use of DOACs was not associated with a significant difference in stroke or systemic embolism, or thrombus resolution, compared with VKA therapy. The use of DOACs was associated with a lower rate of all-cause death and fewer bleeding events.
Study context
- Population
- Patients with left ventricular thrombus22 articles (18 observational, 4 RCTs)
- Participants
- 3,587 patients
- Comparison
- DOAC vs VKA
- DOACn = 1,098
- VKAn = 2,489reference
- Outcome
- Stroke or systemic embolism; thrombus resolution
Methodological detailsrandom-effects model, Risk of bias evident particularly for observational reports; some publication bias suggested in funnel plots
- Random-effects model
- Risk of bias evident particularly for observational reports; some publication bias suggested in funnel plots
Pooled result
As reported in the abstract
- Comparable between DOAC and VKA; low heterogeneity overall
- Random-effects model
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| All-cause death | 0.65 (0.46–0.92) | |
| 0.512Odds ratio (log scale) |
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Composite bleeding endpoint | 0.67 (0.47–0.97) | |
| 0.512Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Oral anticoagulation in patients with left ventricular thrombus: a systematic review and meta-analysis. Eur Heart J Cardiovasc Pharmacother. Published 6 June 2024. doi:10.
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