Heart failure & cardiomyopathies
Association between anti-SSA autoantibodies and conduction disturbances in heart failure
Authors' conclusion
Anti-SSA is independently associated with AVB and BBB in patients with HF.
Study context
- Population
- Patients hospitalised with heart failure (HF) tested for anti-SSA and with ECG, Beijing Anzhen Hospital, Jan 2018–Jun 202270 (9.1%) anti-SSA positive
- Participants
- 766 patients
- Exposure
- Anti-SSA positive vs anti-SSA negative
- Anti-SSA positiven = 70
- Outcome
- Conduction disturbances (AVB, BBB, intraventricular conduction delay)
Methodological detailssingle-centre, ECG conduction disturbances confirmed by a cardiologist blinded to anti-SSA status
- Single-centre
- ECG conduction disturbances confirmed by a cardiologist blinded to anti-SSA status
Main finding
As reported in the abstract
Anti-SSA positive
- Atrioventricular block (AVB) prevalence
- 20%
- Bundle branch block (BBB) prevalence
- 27.3 %
Anti-SSA positive
Atrioventricular block (AVB) prevalence20%
Bundle branch block (BBB) prevalence27.3 %
anti-SSAOdds ratio (95% CI)P value
AVB; adjusted for known risk factors
2.42(1.18–5.43)
P = 0.03BBB; adjusted for known risk factors
3.15(1.68–5.89)
P < 0.001Observational data: associations, not effects.
Original publication
Association between anti-SSA autoantibodies and conduction disturbances in heart failure. Heart Rhythm. Published 5 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →