Acute cardiac care & resuscitationCohort study
Organ perfusion pressure as a hemodynamic target in cardiogenic shock
- Retrospective cohort study
- single-centre
Authors' conclusion
In CS, a higher OPP is independently associated with improved survival, renal preservation, and resource efficiency. OPP provided incremental value especially for renal outcomes.
Study context
- Population
- Adults with cardiogenic shock, MIMIC-IV critical care database (other forms of shock excluded)
- Participants
- 189 adults
- Exposure
- Organ perfusion pressure as prognostic exposure
- Outcome
- In-hospital and ICU mortality
Main finding
As reported in the abstract
In-hospital mortality, per 5 mmHg increase in 24-hour mean OPP
Adjusted odds ratio
0.79
95% CI 0.65–0.96
P = 0.020
Per 5 mmHg increase in 24-hour mean OPP
aOR 0.79 (95% CI 0.65–0.96); P = 0.020
Per 5 mmHg increase in 24-hour mean OPP, as printed
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR | P value |
|---|---|---|
| RRT, higher OPP | 0.65 | P < 0.001 |
Urine output, higher OPP
- Increased urine output
- +0.21 mL/kg/hr, p<0.001
Original publication
Organ perfusion pressure as a hemodynamic target in cardiogenic shock. Eur J Heart Fail. Published 5 May 2026. doi:10.1093/ejhf/xuag149
Summarised from the published abstract; every number is checked against it