Acute cardiac care & resuscitationCohort study
Organ Perfusion Pressure Predicts Outcomes in Cardiogenic Shock Patients
- Prospective cohort study (registry)
- multicentre
- observational
Authors' conclusion
In this multicentre, observational, prospective study on patients hospitalized for CS, lower OPP on admission was associated with significantly higher in-hospital all-cause mortality.
Study context
- Population
- Consecutive patients with AMI-related or acutely decompensated HF-related cardiogenic shock, multicentre Altshock-2 registry, January 2020–November 2023
- Participants
- 316 patients
- Exposure
- Low vs high organ perfusion pressure
- Outcome
- In-hospital all-cause mortality
Main finding
As reported in the abstract
Low OPP vs High OPPEstimate (95% CI)P value
In-hospital all-cause mortality
HR 1.757(1.208–2.556)
P = 0.003adjusted for age and SOFA score
HR per mmHg decrease 1.016(1.004–1.029)
P = 0.010- Overall in-hospital deaths
- 117 (37%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| In-hospital all-cause mortality, low mean arterial pressure alone | 1.323 (0.901–1.941) | P = 0.153 | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR | P value |
|---|---|---|
| In-hospital all-cause mortality, ADHF-CS (subgroup) | 3.172 | P = 0.002 |
Original publication
Organ Perfusion Pressure Predicts Outcomes in Cardiogenic Shock Patients. Eur J Heart Fail. Published 16 February 2025. doi:10.1002/ejhf.3627
Summarised from the published abstract; every number is checked against it