Valvular & structural heart disease
Oscillatory shear stress is elevated in patients with bicuspid aortic valve and aortic regurgitation: a 4D flow cardiovascular magnetic resonance cross-sectional study
Authors' conclusion
OSI uniquely characterizes altered WSS patterns in BAVs with aortic regurgitation, and thus could be a haemodynamic marker specific for this specific group that is at higher risk of aortic complications.
Study context
- Population
- Patients with bicuspid aortic valve (BAV) and normal controls with tricuspid aortic valve undergoing 4D flow CMR57 subjects stated
- Participants
- 14 / 13 / 15 / 22
- Exposure
- BAV with aortic regurgitation vs BAV without valve disease, BAV with aortic stenosis and normal controls
- BAV with aortic regurgitationn = 14
- BAV without valve diseasen = 13
- BAV with aortic stenosisn = 15
- Normal controlsn = 22reference
- Outcome
- WSS during the whole cardiac cycle (peak and time averaged WSS in systole and diastole, OSI) in the ascending aorta
Methodological details4D flow CMR, Student's t-tests or Wilcoxon rank sum tests
- 4D flow CMR
- Student's t-tests or Wilcoxon rank sum tests
Main finding
As reported in the abstract
- Oscillatory shear index (OSI) in BAV with aortic regurgitation twice as high as other groups, mainly outer mid-to-distal ascending aorta
- P ≤ 0.001
Observational data: associations, not effects.
Original publication
Oscillatory shear stress is elevated in patients with bicuspid aortic valve and aortic regurgitation: a 4D flow cardiovascular magnetic resonance cross-sectional study. Eur Heart J Cardiovasc Imaging. Published 25 October 2023. doi:10.
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