Heart failure & cardiomyopathies
Outcomes After Repeat Alcohol Septal Ablation in Patients With Obstructive Hypertrophic Cardiomyopathy
Main finding · Absence of symptomatic residual LV obstruction (NYHA functional class I or LV gradient <50 mm Hg, or both)Result — go to the resultAdjusted odds ratio 4.06 95% CI 1.09–18.3Authors' conclusion
The site of residual obstruction may be important for understanding long-term outcomes after repeat ASA, but this requires further studies.
Study context
- Population
- Patients with obstructive hypertrophic cardiomyopathy who underwent repeat alcohol septal ablation (ASA)repeat ASA, of 663 patients who underwent ASA
- Participants
- 84 patients
- Comparison
- Proximal vs distal residual left ventricular (LV) obstruction
- Proximal obstructionn = 41
- Distal obstructionn = 43reference
- Outcome
- Absence of symptomatic residual LV obstruction (NYHA functional class I or LV gradient <50 mm Hg, or both)
- Follow-up
- 12 months after repeat ASA
Main finding
As reported in the abstract
Adjusted odds ratio
4.06
95% CI 1.09–18.3
Events by group
Proximal obstructionvs distal obstruction
adjusted OR 4.06 (95% CI 1.09–18.3)
- Overall achieved primary endpoint
- 80.7% (67/83)
Secondary outcomes
Deaths · median follow-up of 7.1 years
- Deaths
- 13 deaths (15.5%)
Cardiovascular mortality and heart failure hospitalization
- Similar between proximal and distal obstruction
Fatal arrhythmia and 3rd interventions
- More frequent in distal obstruction
Technical success
- Patients failing to achieve technical success
- Five
Safety
- Death due to infection during the index hospitalization — proximal obstruction
- One events
Original publication
Outcomes After Repeat Alcohol Septal Ablation in Patients With Obstructive Hypertrophic Cardiomyopathy. JACC Adv. Published 14 February 2026. doi:10.
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