Heart failure & cardiomyopathies
Outcomes of conduction system pacing for cardiac resynchronization therapy in patients with heart failure: A multicenter experience
Authors' conclusion
In patients with heart failure and reduced ejection fraction, CSP resulted in greater improvement in LVEF compared to BiVP.
Study context
- Population
- Patients with HF fulfilling cardiac resynchronization therapy (CRT) indicationsmatched cohort
- Participants
- 238 patients
- Exposure
- Conduction system pacing (CSP) vs biventricular pacing (BiVP) for CRT
- BiVPn = 119reference
- Outcome
- CRT response (absolute increase of ≥5% in left ventricular ejection fraction (LVEF))
- Follow-up
- 6 months post-CRT
Methodological detailsmulticentre, propensity-score matched, 1:1, Mean age 69.8 ± 12.5 years; 66 (27.7%) female, His-bundle pacing 69 (29%), left bundle branch area pacing 50 (21%), BiVP 119 (50%)
- Multicentre
- Propensity-score matched
- 1:1
- Mean age 69.8 ± 12.5 years; 66 (27.7%) female
- His-bundle pacing 69 (29%), left bundle branch area pacing 50 (21%), BiVP 119 (50%)
Main finding
As reported in the abstract
CRT responders · 6 months
P = 0.042
Observational data: associations, not effects.
Further findings
Follow-up duration
P = 0.293
- Time to first HF hospitalization · no statistically significant difference
- P = 0.78
- Overall survival · no statistically significant difference
- P = 0.68
Original publication
Outcomes of conduction system pacing for cardiac resynchronization therapy in patients with heart failure: A multicenter experience. Heart Rhythm. Published 24 February 2023. doi:10.
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