Pulmonary vascular disease & thromboembolism
Outpatient Point-of-Care Cardiopulmonary Exercise Testing in Chronic Thromboembolic Pulmonary Disease: A Single-Center Experience
Authors' conclusion
Point-of-care CPET provides objective assessment of gas-exchange improvements after pulmonary revascularization in mild-to-moderate CTEPH/CTEPD.
Study context
- Population
- Patients with chronic thromboembolic pulmonary disease (CTEPD) or chronic thromboembolic pulmonary hypertension (CTEPH) evaluated by a multidisciplinary team, undergoing outpatient point-of-care cardiopulmonary exercise testing (CPET) (SHAPE-HF system) before and after balloon pulmonary angioplasty (BPA)/pulmonary thromboendarterectomy (PTE)patients evaluated, 8 served as controls, 52 underwent revascularization · controls 8 · revascularization 52
- Participants
- 60 patients
- Exposure
- CPET-derived gas-exchange parameters before and after BPA/PTE
- BPAn = 32
- PTEn = 20
- Controlsn = 8
- Outcome
- Change in ventilatory efficiency (VE/VCO2 slope)
Main finding
As reported in the abstract
BPA
43 to 31
VE/VCO2 slope before to after
PTE
42 to 32
VE/VCO2 slope before to after
Observational data: associations, not effects.
Secondary outcomes
| Outcome | BPA | PTE |
|---|---|---|
| 6MWT | before vs after; mean increase 38 m 381 ± 146 vs 419 ± 151 m | before vs after 349 ± 162 vs 358 ± 140 m |
| Shape-HF score | before vs after 2.4 vs 1.5 | before vs after 2.3 vs 1.6 |
- 6MWT: BPA P = 0.03
- 6MWT: PTE P = 0.7
- Shape-HF score: BPA P < 0.001
- Shape-HF score: PTE P = 0.01
WHO-FC
- Improved from class III to I in both groups
- P < 0.001
Correlation of VE/VCO2 with Shape-HF Severity Score and 6MWT
- VE/VCO2 and Shape-HF Severity Score positively correlated
- P < 0.001
- Not with 6MWT
- P = 0.83
Survival · 1-year follow-up
- Survival
- 100%
Original publication
Outpatient Point-of-Care Cardiopulmonary Exercise Testing in Chronic Thromboembolic Pulmonary Disease: A Single-Center Experience. JACC Adv. Published 29 June 2026. doi:10.
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