Heart failure & cardiomyopathies
Outpatient Worsening Among Patients With Mildly Reduced and Preserved Ejection Fraction Heart Failure in the DELIVER Trial
Authors' conclusion
In patients with HF with mildly reduced or preserved ejection fraction, worsening HF requiring oral diuretic intensification in ambulatory care was frequent, adversely prognostic, and significantly reduced by dapagliflozin.
Study context
- Population
- Patients with heart failure (HF) with mildly reduced or preserved EF in the DELIVER trial
- Participants
- 4,532 / 789 / 86 / 585 / 271
- Comparison
- Nonfatal worsening HF event types (outpatient oral diuretic intensification, urgent HF visit, HF hospitalization) vs no worsening HF event; dapagliflozin treatment effect on expanded composite
- No worsening HF eventn = 4,532reference
- Outpatient oral diuretic intensificationn = 789
- Urgent HF visitn = 86
- HF hospitalizationn = 585
- CV deathn = 271
Primary result
As reported in the abstract
Further findings
Outpatient diuretic intensification alone (dapagliflozin vs placebo)
| HR (95% CI) | ||
|---|---|---|
| Dapagliflozin | 0.72 (0.64–0.82) | |
| 0.512Hazard ratio (log scale) |
Expanded composite of worsening HF or CV death (dapagliflozin)
| HR (95% CI) | ||
|---|---|---|
| Dapagliflozin | 0.76 (0.69–0.84) | |
| 0.512Hazard ratio (log scale) |
Patients with an event: adding outpatient diuretic intensification to DELIVER primary end point (CV death, HF hospitalization or urgent HF visit)
- Patients with an event increased from 1122 to 1731
- 54% increase
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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