Acute cardiac care & resuscitation
Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review
Authors' conclusion
Among patients resuscitated from cardiac arrest, neither restrictive oxygen targets nor mild hypercapnia, compared to conventional targets, improved survival or functional outcomes.
Study context
- Population
- Adult patients with sustained return of spontaneous circulation after cardiac arrest, primarily out-of-hospital cardiac arrestsoxygen targets, prehospital setting Five · oxygen targets, intensive care unit setting six · carbon dioxide targets, intensive care unit setting three
- Participants
- 12 trials
- Comparison
- Restrictive to liberal oxygen targets; mild hypercapnia to normocapnia
- Outcome
- Survival or favourable functional outcomes, restrictive vs liberal oxygen targets (prehospital and intensive care unit settings)
Methodological detailsrandom-effects models, GRADE methodology
- Random-effects models
- GRADE methodology
Pooled result
As reported in the abstract
- No differences in survival or favourable functional outcomes
Further pooled results
Outcomes, mild hypercapnia vs normocapnia
- No difference in outcomes
Risk of bias and certainty of evidence
- Risk of bias moderate for most outcomes
- Certainty of evidence low to moderate
Original publication
Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review. Resuscitation. Published 23 April 2025. doi:10.
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