Acute cardiac care & resuscitation
Model for end-stage liver disease incorporating albumin score is associated with short- and long-term all-cause mortality in patients with acute myocardial infarction complicated by cardiogenic shock
Authors' conclusion
Liver injury, quantified as MELD-albumin score, was significantly associated with short- and long-term all-cause mortality among patients with AMICS.
Study context
- Population
- Patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) admitted between 2010 and 2017 who survived until Day 3 and had complete laboratory data availableincluded from a retrospective cohort of 1716 consecutive patients with AMICS
- Participants
- 717 patients
- Exposure
- Patients were stratified into tertiles: low, intermediate, and high MELD-albumin
- Outcome
- All-cause mortality
- Follow-up
- Up to 14 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
High MELD-albumin
- 30 days
- 49%
- 10 years for 30-day survivors
- 58%
Intermediate MELD-albumin
- 30 days
- 35%
- 10 years for 30-day survivors
- 46%
Low MELD-albumin
- 30 days
- 26%
- 10 years for 30-day survivors
- 37%
30 days
High MELD-albumin49%
Intermediate MELD-albumin35%
Low MELD-albumin26%
10 years for 30-day survivors
High MELD-albumin58%
Intermediate MELD-albumin46%
Low MELD-albumin37%
high MELD-albuminAdjusted hazard ratio (95% CI)P value
30 days
2.02(1.49–2.74)
P < 0.00110 years
1.86(1.18–2.92)
P < 0.001Observational data: associations, not effects.
Further findings
Baseline characteristics of the high-score group
- Patients in the high-score group were more often female, had lower left ventricular ejection fraction, had higher lactate levels, and less suffered out-of-hospital cardiac arrest
Prediction of 30-day mortality by MELD-albumin score
- Area under the receiver operating curve
- 0.63 (95% CI: 0.59-0.67)
Original publication
Model for end-stage liver disease incorporating albumin score is associated with short- and long-term all-cause mortality in patients with acute myocardial infarction complicated by cardiogenic shock. Eur Heart J Acute Cardiovasc Care. Published 23 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it