Arrhythmias & electrophysiology
Pacemaker lead insertion sites contribute to abnormalities of myocardial function and histopathology
Authors' conclusion
Lead insertion site-associated regional wall motion abnormalities are common and associated with systemic ventricular dysfunction. Histopathological alterations including myocardial compression, fibrosis, and calcifications beneath active leads may explain this finding.
Study context
- Population
- Patients with a ventricular pacing lead (median age 19 years; range 3–57 years; 47% female in cardiac computed tomography (CCT) group)122 lead insertion sites on CCT
- Participants
- 43 vs 3
- Exposure
- CCT vs Histology
- CCTn = 43
- Histologyn = 3
- Outcome
- Regional wall motion abnormalities at lead insertion sites on cine CCT
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Lead insertion sites with regional wall motion abnormalities
51 of 122
42%
Patients with regional wall motion abnormalities
23 of 43
53%
Prevalence of lead insertion-associated regional wall motion abnormality, active pacing vs not
55% vs 18%
P < .001
Observational data: associations, not effects.
Further findings
Median
| Outcome | With abnormalities | Without abnormalities | P value |
|---|---|---|---|
| Systemic ventricular EF, with vs without lead insertion-associated regional wall motion abnormalities | 38% | 53% | P < 0.001 |
- Prevalence of lead insertion-associated regional wall motion abnormality, active pacing vs not · 55% vs 18%
- P < 0.001
Histopathology beneath active leads (10 epicardial lead insertion sites)
- Myocardial compression, fibrosis and calcifications commonly present directly under active leads
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →