Arrhythmias & electrophysiology
Prophylactic Colchicine After Radiofrequency Ablation of Atrial Fibrillation: The PAPERS Study
Authors' conclusion
Prophylactic colchicine therapy initiated after the ablation procedure in patients with AF did not affect the incidence of post-ablation pericarditis and was associated with an increased incidence of gastrointestinal side effects.
Study context
- Population
- Patients undergoing radiofrequency ablation for atrial fibrillation (AF)
- Participants
- 139 patients
- Comparison
- Prophylactic colchicine vs no prophylaxis after AF ablation
- Group An = 66reference
- Group Bn = 73
- Primary endpoint
- Clinical pericarditis
- Follow-up
- Within 2 weeks following ablation
Methodological detailsmulticentre, prospective, Follow-up survey at 14 days postoperatively
- Multicentre
- Prospective
- Follow-up survey at 14 days postoperatively
Primary result
As reported in the abstract
P = 0.84
Secondary outcomes
Pericarditis by ablation type: cavotricuspid isthmus ablation in addition to PVI vs PVI
- Cavotricuspid isthmus ablation in addition to PVI: 17 of 50
- 34%
- PVI: 6 of 69
- 8.7%
- Difference
- P = 0.001
Safety
Gastrointestinal discomfort
P < 0.001
Original publication
Prophylactic Colchicine After Radiofrequency Ablation of Atrial Fibrillation: The PAPERS Study. JACC Clin Electrophysiol. Published 19 April 2023. doi:10.
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