Arrhythmias & electrophysiology
Colchicine to Prevent Atrial Fibrillation Recurrence After Catheter Ablation: A Randomized, Placebo-Controlled Trial
Authors' conclusion
Colchicine administered for 10 days following catheter ablation did not reduce atrial arrhythmia recurrence or AF-associated clinical events, but did reduce postablation chest pain and increase diarrhea.
Study context
- Population
- Patients scheduled for atrial fibrillation (AF) catheter ablation (radiofrequency 79%, cryoballoon 21%)modified ITT population
- Participants
- 199 patients
- Comparison
- Colchicine vs placebo after AF catheter ablation
- Primary endpoint
- Atrial arrhythmia recurrence (AF, atrial flutter or atrial tachycardia >30 s on 14-day Holters)
- Follow-up
- 2 weeks and 3 months after ablation
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Atrial arrhythmia recurrence · 2 weeks and 3 months
Colchicine
- 2 weeks
- 31%
- 3 months
- 14%
Placebo
- 2 weeks
- 32%
- 3 months
- 15%
2 weeks
Colchicine31%
Placebo32%
3 months
Colchicine14%
Placebo15%
Colchicine vs PlaceboHazard ratio (95% CI)P value
2 weeks
0.98(0.59–1.61)
P = 0.923 months
0.95(0.45–2.02)
P = 0.89Further findings
| Outcome | Colchicine | Placebo | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postablation chest pain consistent with pericarditis | 4% | 15% | 0.26 (0.09–0.77) | P = 0.02 | |
| Composite of ED visit, CV hospitalization, cardioversion or repeat ablation · median follow-up 1.3 years | 29 per 100 patient-years | 25 per 100 patient-years | 1.18 (0.69–1.99) | P = 0.55 | |
| 0.050.21520Hazard ratio (log scale) |
Safety
| Outcome | Colchicine | Placebo | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Diarrhoea | 26% | 7% | 4.74 (1.95–11.53) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Colchicine to Prevent Atrial Fibrillation Recurrence After Catheter Ablation: A Randomized, Placebo-Controlled Trial. Circ Arrhythm Electrophysiol. Published 21 December 2023. doi:10.
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