Particulate Matter Air Pollution and Long-Term Outcomes in Patients Undergoing Percutaneous Coronary Intervention
Authors' conclusion
Veterans undergoing elective PCI are at increased risk of MACE and significant life years lost with long-term exposure to fine particulate matter pollution, even at the current low levels in the United States.
Study context
- Population
- US veterans undergoing elective percutaneous coronary interventions (PCI), 2005–2018median follow-up 6.75 years
- Participants
- 73,425 veterans
- Exposure
- Chronic ambient PM2.5 exposure
- Outcome
- MACE:
- MI
- Stroke
- All-cause mortality
Main finding
As reported in the abstract
MACE per 1-μg/m3 increase in PM2.5
Increase in MACE per 1-μg/m3 increase in PM2.5 (adjusted)
8.7%
95% CI 8.4%–8.9%; P < 0.001
Observational data: associations, not effects.
Further findings
MACE incidence (whole cohort) · 5, 10 and 15 years
- MACE at 5 years
- 28%
- MACE at 10 years
- 48%
- MACE at 15 years
- 65%
Months of life lost, 10 vs 5 μg/m3 PM2.5 · 5, 10 and 15 years of exposure
- Months lost at 5 years
- 1.1
- Months lost at 10 years
- 3.8
- Months lost at 15 years
- 7.6
- Flexible parametric models
Mean annual PM2.5 exposure
- Mean annual PM2.5 exposure (± SD)
- 8.4 ± 1.8 μg/m3
Original publication
Particulate Matter Air Pollution and Long-Term Outcomes in Patients Undergoing Percutaneous Coronary Intervention. JACC Adv. Published 24 February 2023. doi:10.
Summarised from the published abstract; every number is checked against it