Air Pollution and Adverse Cardiovascular Events After Coronary Artery Bypass Grafting: A 10-Year Nationwide Study
Main finding · 10-year MACE by PM2.5 exposureResult — go to the resultHazard ratio 1.27 95% CI 1.10–1.46Authors' conclusion
In this large nationwide CABG cohort, ambient PM2.5 air pollution was strongly associated with adverse 10-year cardiovascular outcomes.
Study context
- Population
- US veterans who underwent coronary artery bypass grafting (CABG) (2010–2019)5-year median follow-up
- Participants
- 26,403 veterans
- Exposure
- Higher vs lower ambient PM2.5 exposure
- Outcome
- MACE:
- MI
- Stroke
- CV death
- Follow-up
- 10 years
Methodological detailsnationwide, multivariable Cox proportional hazard model
- Nationwide
- Multivariable Cox proportional hazard model
Main finding
10-year MACE by PM2.5 exposure
Hazard ratio
1.27
95% CI 1.10–1.46
P < 0.001
By group
10 μg/m3 increase in PM2.5
HR 1.27 (95% CI 1.10–1.46); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
PM2.5 exposure
- Median PM2.5 exposure, μg/m3 (IQR 7.0-8.9)
- 7.9
- Patients exposed to PM2.5 above 5 μg/m3
- 95%
Major adverse cardiovascular events (MACE) attributable to PM2.5
- Share of total MACE attributable to PM2.5 exposure
- 10%
- Potential absolute reduction in 10-year MACE rates if maximum PM2.5 reduced to 5 μg/m3
- 7%
- Simulated (WHO standard 5 μg/m3)
Original publication
Air Pollution and Adverse Cardiovascular Events After Coronary Artery Bypass Grafting: A 10-Year Nationwide Study. JACC Adv. Published 21 December 2023. doi:10.
Summarised from the published abstract; every number is checked against it