Aortic & peripheral vascular disease
Pathological Analysis of Medial and Intimal Calcification in Lower Extremity Artery Disease: Impact of Hemodialysis
Authors' conclusion
Hemodialysis patients demonstrated a higher degree of medial and intimal calcification compared with non-HD patients. The difference was more prominent in the medial calcification of below-the-knee lesions.
Study context
- Population
- Patients with lower extremity artery disease who underwent autopsy or lower limb amputation77 arteries
- Participants
- 36 patients
- Comparison
- Hemodialysis (HD) vs non-HD patients
- HDn = 21
- Non-HDn = 15reference
- Outcome
- Lesion characteristics of lower extremity artery disease (medial and intimal calcification)
Main finding
As reported in the abstract
Medial calcification arc
- HD vs Non-HD: P < 0.0001
Further findings
| Outcome | OR | P value |
|---|---|---|
| Severe medial calcification (arc ≥180°), below-the-knee lesionsMultivariable analysis | 17.1 | P = 0.02 |
| Intimal calcification, above-the-knee lesions | P = 0.02 | |
| Severe bone formationMore common in HD | P = 0.01 |
- Intimal calcification, above-the-knee lesions: significantly higher in HD, with higher prevalence of advanced atherosclerotic plaque
Original publication
Pathological Analysis of Medial and Intimal Calcification in Lower Extremity Artery Disease: Impact of Hemodialysis. JACC Adv. Published 19 October 2023. doi:10.
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