Patient characteristics, valve surgery and 1-year mortality in left-sided Staphylococcus aureus infective endocarditis: a nationwide study
Authors' conclusion
In patients with SA-IE, surgical patients were younger and had fewer comorbidities, but had more severe disease status at admission, compared with non-surgical patients. Surgery was associated with lower 1-year mortality, but the heterogeneity of this patient population limits firm conclusions about the superiority of either treatment strategy.
Study context
- Population
- Patients with left-sided Staphylococcus aureus infective endocarditis (SA-IE) in the NatIonal Danish endocarditis stUdieS registry, 2016–2021patients identified
- Participants
- 918 patients
- Exposure
- Surgical vs non-surgical treatment
- Surgicaln = 160
- Non-surgicaln = 758reference
- Outcome
- Crude in-hospital mortality
- Follow-up
- In-hospital
Methodological detailsregistry
- Registry
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Crude 1-year mortality
Baseline characteristics · admission
Median age surgical 63.7 years · non-surgical 75.0 years
Male
Diabetes
Congestive heart failure
Larger vegetations
Sepsis
Emboli
| Outcome | HR (95% CI) | |
|---|---|---|
| Adjusted in-hospital mortalityAdjusted for confounders | 0.75 (0.47–1.19) | |
| Adjusted 1-year mortalityStatistically significantly lower in surgical patients · adjusted for confounders | 0.61 (0.41–0.91) | |
| 0.512Hazard ratio (log scale) |
Original publication
Patient characteristics, valve surgery and 1-year mortality in left-sided Staphylococcus aureus infective endocarditis: a nationwide study. Heart. Published 20 November 2025. doi:10.
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