Heart failure & cardiomyopathies
Patient-Reported Frailty and Functional Status in Heart Failure With Preserved Ejection Fraction: Insights From VITALITY-HFpEF
Authors' conclusion
Patient-reported frailty is modestly correlated with both the KCCQ-PLS and 6MWD but offers prognostic insight into 6MWD at 24 weeks.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) in the VITALITY-HFpEF trial, frailty by patient-reported Fried frailty phenotype symptoms
- Participants
- 739 patients
- Comparison
- Frailty categories
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
Baseline frailty prevalence, KCCQ-PLS and 6MWD by frailty status
| Group | Value | Kansas City Cardiomyopathy Questionnaire Physical Limitation Score (KCCQ-PLS) mean ± SD | 6MWD mean ± SD |
|---|---|---|---|
| Not frail | 27.3% | 68.2 ± 23.2 | 328.5 ± 117.1 m |
| Prefrail | 37.6% | 61.7 ± 22.6 | 310.8 ± 98.9 m |
| Frail | 35.0% | 48.4 ± 23.8 | 250.7 ± 104.3 m |
Value
Not frail27.3%
Prefrail37.6%
Frail35.0%
Kansas City Cardiomyopathy Questionnaire Physical Limitation Score (KCCQ-PLS) mean ± SD
Not frail68.2 ± 23.2
Prefrail61.7 ± 22.6
Frail48.4 ± 23.8
6MWD mean ± SD
Not frail328.5 ± 117.1 m
Prefrail310.8 ± 98.9 m
Frail250.7 ± 104.3 m
- Differences across frailty categories in KCCQ-PLS and 6MWD
- P < 0.01 for both
Further findings
Association with 6MWD at 24 weeks (adjusted for baseline 6MWD)
- Baseline frailty status, but not KCCQ-PLS, significantly associated with 6MWD at 24 weeks
Change in frailty status · 24 weeks
- No change in frailty
- 47.5%
- Became less frail
- 45.5%
- Became more frail
- 7.0%
Effect of vericiguat on frailty · 24 weeks
- Vericiguat did not alter frailty status
Original publication
Patient-Reported Frailty and Functional Status in Heart Failure With Preserved Ejection Fraction: Insights From VITALITY-HFpEF. JACC Heart Fail. Published 1 February 2023. doi:10.
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