Patterns of Restenosis After Left Main Bifurcation Single- or Dual-Stenting: An EBC MAIN Trial Subanalysis
Authors' conclusion
The circumflex ostium is the commonest site requiring revascularization after LM bifurcation stenting, irrespective of whether 1 or 2 stents were deployed.
Study context
- Population
- Patients from the EBC MAIN trial with target lesion revascularization after left main (LM) bifurcation stenting during 3-year follow-uppatients with TLR
- Participants
- 48 patients
- Comparison
- Dual-stenting vs single-stenting of LM bifurcation
- Dual-stentedn = 35
- Single-stentedn = 13reference
- Primary endpoint
- Restenosis location (≥50% lesion diameter stenosis) and impact of stent implantation technique
- Follow-up
- 3-year follow-up
Methodological detailscore laboratory assessment
- Core laboratory assessment
Primary result
As reported in the abstract
Restenosis location
P = 0.115
- Commonest pattern: isolated ostial circumflex restenosis, regardless of dual- or single-stent implantation
- 58%
- Ostial circumflex culprit lesion for TLR overall
- 34 (71%)
Further findings
| Outcome | Dual-stented | Single-stented | Coefficient (95% CI) | P value | |
|---|---|---|---|---|---|
| Mean % diameter stenosis at the LCx ostium · 3-year follow-upDual vs Single | mean 64.6% | Not reported in the abstract | −0.12 (−0.46 to 0.22) | P = 0.473 | Single-stented: not reported in the abstract |
| Mean % diameter stenosis at the LAD ostium, single stenting (subgroup) · 3-year follow-upLM to circumflex vs LM- left anterior descending · worse with LM to circumflex | 0.57 (0.003–1.13) | P = 0.049 |
- Mean % diameter stenosis at the LCx ostium: Single mean 60.5%
- Mean % diameter stenosis at the LAD ostium, single stenting (subgroup): LM to circumflex mean 49.8%
- Mean % diameter stenosis at the LAD ostium, single stenting (subgroup): LM- left anterior descending mean 19.8%
Original publication
Patterns of Restenosis After Left Main Bifurcation Single- or Dual-Stenting: An EBC MAIN Trial Subanalysis. Circ Cardiovasc Interv. Published 17 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it