Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: The pCAD-POAF Randomized Clinical Trial
Primary resultResult — go to the resultRelative risk 0.57 95% CI 0.41–0.81Authors' conclusion
This randomized clinical trial found that partial cardiac denervation was an effective procedure to reduce the occurrence of POAF after isolated CABG without additional postoperative complications.
Study context
- Population
- Adults scheduled for isolated coronary artery bypass grafting (CABG) in China
- Participants
- 430 adults
- Comparison
- CABG plus partial cardiac denervation vs CABG only
- Primary endpoint
- Incidence of postoperative atrial fibrillation (POAF) (supraventricular arrhythmia lasting >30 seconds)
- Follow-up
- 6 days
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Relative risk
0.57
95% CI 0.41–0.81
P = 0.001
By group
Intervention vs Control
RR 0.57 (95% CI 0.41–0.81); P = 0.001
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| POAF occurrence, Kaplan-Meier sensitivity analysis · sensitivity analysis | 0.53 (0.36–0.79) | P = 0.002 | |
| 0.20.5125Hazard ratio (log scale) |
Postoperative medical cost
- Reduced in the intervention group
Safety
Safety assessments
- No difference between the 2 groups
Original publication
Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: The pCAD-POAF Randomized Clinical Trial. JAMA Cardiol. Published 1 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it