Arrhythmias & electrophysiology
Participant Engagement and Preference Study for Clinical Outcomes Associated With Atrial Fibrillation: The PEARL-AF Study
Authors' conclusion
Patients expressed relatively high levels of concern about major bleeding compared to moderate-severity stroke or systemic embolism, endpoints frequently used in AF trials.
Study context
- Population
- Patients with AF
- Participants
- 1,028 patients
- Outcome
- Relative importance (best-worst scaling weights) of AF-related events
Methodological detailspreference survey, best-worst scaling
- Preference survey
- Best-worst scaling
Main finding
As reported in the abstract
Best-worst scaling importance weights (death reweighted to 1)
- Death
- 1
- Severe disabling stroke
- 0.83
- Major bleeding
- 0.53
- Myocardial infarction (MI) with heart failure (HF)
- 0.50
- Moderate-severity stroke
- 0.28
- Systemic embolism
- 0.13
- Clinically relevant nonmajor bleeding
- 0.10
- MI without HF
- 0.06
- Minor stroke
- 0.04
Observational data: associations, not effects.
Further findings
Event ranking by age, sex and race (subgroups)
- Event order consistent across age, sex and race; relative weights varied by sex and race
Original publication
Participant Engagement and Preference Study for Clinical Outcomes Associated With Atrial Fibrillation: The PEARL-AF Study. JACC Adv. Published 26 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →