Heart failure & cardiomyopathies
Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates Heart Failure with Preserved Ejection Fraction (HFpEF)
Authors' conclusion
In HFpEF, %PredO2P is a VVR marker that can stratify invasive parameters such as percent predicted peak stroke volume. %PredO2P is an independent prognostic marker for all-cause mortality and those with higher %PredO2P exhibited longer survival.
Study context
- Population
- HFpEF patients who underwent invasive CPETgrouped into %PredO2P tertiles
- Participants
- 154 patients
- Outcome
- Association of %PredO2P with ventricular-vascular response (VVR) markers and with all-cause mortality
- Follow-up
- Median 5.6 years
Methodological detailsMean age 57 ± 15 years
- Mean age 57 ± 15 years
Main finding
As reported in the abstract
- %PredO2P vs effective arterial elastance, r
- −0.45, P < 0.001
- %PredO2P vs proportionate pulse pressure, r
- −0.22, P = 0.008
- %PredO2P vs %PredVO2, r
- 0.61, P < 0.001
- All-cause mortality per percent increase in %PredO2P, HR (adjusted for age and BMI)
- 0.95, 95% CI 0.92-0.98, P = 0.003
- Deaths
- 15%
Observational data: associations, not effects.
Further findings
- Higher %PredO2P correlated with higher exercise capacity
- %PredO2P distinguished normal and abnormal percent predicted peak stroke volume
Original publication
Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF. JACC Adv. Published 12 July 2024. doi:10.
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