Percutaneous coronary intervention versus medical therapy in stable angina: a matched cohort study
Main findingResult — go to the resultHazard ratio 1.18 95% CI 1.06–1.32Authors' conclusion
PCI plus OMT was associated with higher rate of primary endpoint of MI, stroke, cardiac death as compared with OMT alone in patients with pure stable angina at 9.3-year follow-up in large population.
Study context
- Population
- Patients with pure stable angina, no history of myocardial infarction (MI) or percutaneous coronary intervention (PCI), enrolled 2006–201058,742 candidates
- Participants
- 5,673 vs 5,673
- Exposure
- PCI plus optimal medical therapy (OMT) vs OMT alone
- PCIn = 5,673
- OMTn = 5,673reference
- Outcome
- Composite of:
- MI
- Stroke
- Cardiac death
- Follow-up
- 9.3 years
Methodological detailspropensity-score matched (1:1), Korean national insurance data
- Propensity-score matched (1:1)
- Korean national insurance data
Main finding
As reported in the abstract
Hazard ratio
1.18
95% CI 1.06–1.32
P = 0.003
By group
PCI
13.5/1000
person-year
OMT
11.5/1000
person-year
PCIvs OMT
HR 1.18 (95% CI 1.06–1.32); P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | PCI | OMT | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| MI · 9.3 years | 2.9 | 2.1 | 1.38 (1.09–1.7) | P = 0.009 | |
| Cardiac death · 9.3 years | 4.8 /1000 person-year | 3.4 /1000 person-year | 1.40 (1.16–1.69) | P = 0.001 | |
| Revascularisation | 30.3 | 8.2 | 3.64 (3.27–4.05) | P < 0.001 | |
| Total death | 13.5 /1000 person-year | 10.6 /1000 person-year | 1.23 (1.12–1.40) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Subgroups
- Same trend of more events in the PCI group
Original publication
Percutaneous coronary intervention versus medical therapy in stable angina: a matched cohort study. Heart. Published 29 January 2024. doi:10.
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