Valvular & structural heart disease

Percutaneous Edge-to-Edge Repair of Atrioventricular Valves in Congenital Heart Disease: A Multicenter Clinical Experience

JACC AdvPublished Retrospective cohort study

Authors' conclusion

TEER for carefully selected patients with CHD and severe AVVR was safe and effective with notable improvements in regurgitation and clinical symptoms.

Study context

Population
Patients with congenital heart disease (CHD) and symptomatic 3+ or 4+ atrioventricular valve regurgitation (AVVR) undergoing atrioventricular transcatheter edge-to-edge repair (TEER)18 reached 6-month follow-up
Participants
20 patients
Outcome
AVVR reduced from 3+/4+ at baseline to mild-to-moderate (1+ to 2+)
Follow-up
30 days
Methodological detailsmulticentre, 5 medical centers
  • Multicentre
  • 5 medical centers

Main finding

As reported in the abstract

Patients with AVVR reduced to mild-to-moderate (1+ to 2+)
19 (95.0%)
P value
P < 0.001

Observational data: associations, not effects.

Further findings

NYHA class III-IV · 30 days

NYHA class III-IV at baseline
18 (90.0%)
NYHA class III-IV at 30 days
10.5%

Death (intractable HF) · first 30 days

Deaths
1 (5.0%)

Original publication

Percutaneous Edge-to-Edge Repair of Atrioventricular Valves in Congenital Heart Disease: A Multicenter Clinical Experience. JACC Adv. Published 4 December 2025. doi:10.1016/j.jacadv.2025.102408

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