Optical Coherence Tomography to Better Assess Chronic Total Occlusion Percutaneous Intervention Results: The PERFECTO Study
Authors' conclusion
CTO-percutaneous coronary intervention could affect stent healing with a high incidence of immediate and late-acquired malapposition.
Study context
- Population
- Patients with successful CTO recanalization >20 mm in length, all receiving the same last-generation drug-eluting stent
- Participants
- 114 patients7 centres
- Exposure
- Stent strut apposition at the index CTO procedure vs 3-month follow-up
- Outcome
- Stent strut apposition (rate of malapposed struts per patient) by FD-OCT
- Follow-up
- index procedure and 3-month follow-up
Methodological detailsmulticentre (7 centres), consecutive patients
- Multicentre (7 centres)
- Consecutive patients
Main finding
As reported in the abstract
Malapposed struts per patient
P < 0.0001
Observational data: associations, not effects.
Further findings
Distal vessel minimal lumen area · 3-month follow-up
increase 69% · P < 0.0001
| Outcome | P value |
|---|---|
| Malapposed struts by techniqueDissection and re-entry / subintimal stenting vs Intimal techniques | P = 0.02 |
- Malapposed struts by technique: Dissection and re-entry / subintimal stenting 12.8%
- Malapposed struts by technique: Intimal techniques 5.3%
Safety
- No complication occurred with frequency-domain optical coherence tomography (FD-OCT)
Original publication
Optical Coherence Tomography to Better Assess Chronic Total Occlusion Percutaneous Intervention Results: The PERFECTO Study. JACC Adv. Published 9 September 2025. doi:10.
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