Performance of the American Heart Association’s PREVENT Equations Among Disaggregated Racial and Ethnic Subgroups
Authors' conclusion
The PREVENT equations appropriately predicted risk in contemporary diverse Asian and Hispanic subgroups with modest variation in performance across disaggregated subgroups.
Study context
- Population
- Primary care patients aged 30–79 years, Sutter Health, Northern California, 2010–2023, free from Cardiovascular Disease (CVD) at baseline
- Participants
- 361,778 patients
- Exposure
- PREVENT equations performance across racial and ethnic subgroups
- Asiann = 81,424
- Hispanicn = 40,897
- Outcome
- CVD events (ICD codes as in the PREVENT derivation); PREVENT model performance (C statistic, calibration slope)
- Follow-up
- Mean 8.1 years
Methodological detailselectronic health record-based
- Electronic health record-based
Main finding
As reported in the abstract
Total CVD: discrimination and calibration
| Group | C statistic | Calibration slope |
|---|---|---|
| Asian | 0.83 (95% CI, 0.82-0.84) | 0.84 (95% CI, 0.78-0.90) |
| Hispanic | 0.80 (95% CI, 0.79-0.81) | 1.02 (95% CI, 0.94-1.10) |
C statistic
Asian0.83 (95% CI, 0.82-0.84)
Hispanic0.80 (95% CI, 0.79-0.81)
Calibration slope
Asian0.84 (95% CI, 0.78-0.90)
Hispanic1.02 (95% CI, 0.94-1.10)
- Asian subgroups: C statistic from Filipino to Asian Indian
- 0.79 (95% CI, 0.77-0.81) to 0.85 (95% CI, 0.83-0.87)
- Hispanic subgroups: C statistics similar, total CVD
- between 0.80 and 0.82
Observational data: associations, not effects.
Further findings
Overall CVD events · mean follow-up 8.1 years
- CVD events
- 22 648 (6.3%)
ASCVD and HF PREVENT equations
- Small differences in performance among racial and ethnic groups and subgroups
Original publication
Performance of the American Heart Association’s PREVENT Equations Among Disaggregated Racial and Ethnic Subgroups. JAMA Cardiol. Published 1 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it