Sudden cardiac death after early-onset myocardial infarction: a multicentre longitudinal cohort study with a 20-year follow-up
Authors' conclusion
Sudden cardiac death frequently occurs during the 20 years after early-onset MI. The nature of the identified predictors and the absence of clustering suggest that the pathophysiological basis of SCD may be related to progressive coronary atherosclerosis.
Study context
- Population
- Patients with a first myocardial infarction (MI) before age 45 years (Italian Genetic Study on Early-onset MI)
- Participants
- 2,000 patients
- Outcome
- SCD (predictors of SCD after early-onset MI)
- Follow-up
- Median 19.9 years
Methodological detailsnationwide, Fine-Gray proportional hazard models
- Nationwide
- Fine-Gray proportional hazard models
Main finding
As reported in the abstract
SCD · median 19.9 years
Sudden cardiac death (SCD) occurred
195 patients
Observational data: associations, not effects.
Further findings
Timing of SCD
- SCD as first post-MI clinical event
- 101 patients
- SCD after non-fatal MI or hospitalisation for coronary revascularisation
- 94
- No clear evidence of clustering of SCD events during follow-up
Original publication
Sudden cardiac death after early-onset myocardial infarction: a multicentre longitudinal cohort study with a 20-year follow-up. Eur Heart J Acute Cardiovasc Care. Published 6 August 2024. doi:10.
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