Prevention & lipidsCohort study
Peripheral autonomic dysregulation in response to standing: a new form associated with cardiovascular disease, mobility reduction, and cognitive alterations
- Prospective cohort study
- two prospective cohorts
Authors' conclusion
These findings reveal a novel variant of the autonomic cardiovascular response to standing, with important clinical implications for functional decline in older adults.
Study context
- Population
- Young (Melbourne) and older (Ireland) adults undergoing active standing with real-time haemodynamic recording3,074 young, 3025 older
- Exposure
- Initial orthostatic cardiac output (CO) fall vs rise
- Outcome
- Patterns of orthostatic cardiac output responses, their physiological determinants and clinical relevance
Main finding
As reported in the abstract
Initial orthostatic CO response pattern (prevalence)
Young
Older
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Falls, subjects on negatively chronotropic drugs (subgroup, n = 487) | 1.82 (1.18–2.80) | |
| 0.20.5125Odds ratio (log scale) |
Clinical correlates of COF (older adults)
- After adjustment, COF associated with slower gait, frailty and diminished cognitive function
- P < 0.001
- COF more prevalent with CVD, higher BMI, smoking, diabetes or antihypertensive use
- all P < .001
Original publication
Peripheral autonomic dysregulation in response to standing: a new form associated with cardiovascular disease, mobility reduction, and cognitive alterations. Eur Heart J. Published 30 January 2026. doi:10.1093/eurheartj/ehaf1120
Summarised from the published abstract; every number is checked against it