Arrhythmias & electrophysiology
Personalized Heart Digital Twins Detect Substrate Abnormalities in Scar-Dependent Ventricular Tachycardia
Authors' conclusion
Digital twin-predicted sites display a higher prevalence of abnormal and prolonged electrograms compared with nonpredicted sites and accurately identify regions of conduction slowing.
Study context
- Population
- Patients with scar-dependent ventricular tachycardia (VT) undergoing catheter ablationpatients with scar-dependent VT
- Participants
- 18 patients
- Comparison
- Digital twin-predicted sites vs nonpredicted sites
- Outcome
- Electrogram abnormalities and regions of conduction slowing at digital twin-predicted vs nonpredicted sites
Performance
As reported in the abstract
Electrogram abnormalities
P < 0.001
Further findings
Electrogram duration
P < 0.001
Deceleration zones on isochronal late activation mapping correctly identified
- Deceleration zones correctly identified by digital twins
- 21 of 26 (80.8%)
Original publication
Personalized Heart Digital Twins Detect Substrate Abnormalities in Scar-Dependent Ventricular Tachycardia. Circulation. Published 6 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it