Cardio-oncology & otherSecondary analysis
Phenotypes of Myocardial Dysfunction on Serial Echocardiography and Cardiac Magnetic Resonance (CMR) in Women With Early-Stage Breast Cancer
- Secondary analysis of the EMBRACE-MRI prospective study
Authors' conclusion
Patients receiving breast cancer therapy can develop significant GLS change, DD, or CMR-defined CTRCD that can occur in isolation, concurrently, or sequentially. Development of DD is associated with ECV and higher risk for subsequent CTRCD.
Study context
- Population
- Women with early-stage HER2+ breast cancer receiving cancer therapy
- Participants
- 136 women
Primary result
As reported in the abstract
Left ventricular (LV) dysfunction phenotypes during cancer therapy
- Cancer therapy-related cardiac dysfunction (CTRCD) (CMR-derived LVEF)
- 37 of 136 (27%)
- Worsening global longitudinal strain (GLS) (relative reduction >15%), analyzable studies
- 53 of 126 (42%)
- Incident diastolic dysfunction (DD), conventional grading
- 25 (19.4%) of 129
- Incident DD, modified grading (left atrial reservoir strain (LARS) <24%)
- 19 (14.4%) of 132
- Subsequent CTRCD after first transition to DD
- 5 of 8 [63%]
- Subsequent CTRCD after first transition to worsening GLS
- 7 of 39 [18%]
- Worsening DD and subsequent CTRCD, OR
- 20.9 (3.4-129.5) (95% CI)
- Worsening GLS and subsequent CTRCD, OR
- 4.9 (2.6-9.4) (95% CI)
Original publication
Phenotypes of Myocardial Dysfunction on Serial Echocardiography and CMR in Women With Early-Stage Breast Cancer. JACC Cardiovasc Imaging. Published 19 March 2025. doi:10.1016/j.jcmg.2024.12.010
Summarised from the published abstract; every number is checked against it